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Pathology General 302251e5

Which antibodies in mother with SLE is responsible for congenital heart disease in child-

A
Anti-histone
B
Anti-Ro & Anti-LA
C
Anti ds DNA
D
Anti-centromere
High-Yield Explanation
Most sensitive → Antinuclear antibody (ANA) Most specific → Anti-double stranded antibody and the antibody against Smith (Sm) Associated with neonatal lupus and congenital heart block → Anti Ro, Anti LA antibody Associated with lupus psychosis → Anti P antibody

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