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Pathology General 30064418

What is the main feature of chemotaxis as observed in white blood cells?

A
Increased random movement of neutrophils
B
Increased adhesiveness to intima
C
Increased phagocytosis
D
Unidirectional locomotion of neutrophils
High-Yield Explanation
Chemotaxis is defined as unidirectional movement of leukocytes up a concentration gradient of chemotactic molecules. All granulocytes, monocytes and to a lesser extent lymphocytes respond to chemotactic stimuli with varying rates of speed. Chemoattractants are exogenous or endogenous in nature. Exogenous agents are bacterial products. Endogenous mediators are:Components of complement pathway C5aProducts of lipoxygenase pathway LTB4Cytokines paicularly those of chemokine familyRef: Robbins Pathologic Basis of Disease, 6th Edition, Page 61

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