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Pharmacology General 2f5a2ce8

Amiloride can cause hyperkalemia due to its action on :

A
Electrogenic K+ channels
B
Electrogenic Na+ channels
C
Non electrogenic Na+-C1- symporter
D
H+-K+ ATPase
High-Yield Explanation
Amiloride and triamterene are K+ sparing diuretics that act by inhibiting epithelial Na+ channels. In the distal tubules and collecting ducts, three separate channels are present (one for Na+, K+ and H+ each). Aldosterone acts on DCT and CD to cause reabsorption of Na+. This generates a lumen negative potential difference across the membrane of this part of the nephron. To maintain the electric neutrality, K+ and H+ are secreted in the lumen.

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