Centrilobular necrosis of liver may be seen with -

Ans. is 'c' i.e., CC14 Hepatocellular necrosis: - o Liver necrosis is a common manifestation of many liver diseases and it can present in various ways, o If severe it can cause liver failure. o In some cases however the necrosis is subclinical, revealed only by elevations of liver enzymes in serum, o Various diseases can cause different patterns of necrosis. These are -] Focal Necrosis - Randomly occurring necrosis of single cells or small clusters of cells. It can involve any area of the lobule All lobules are not involved. Characteristic features on biopsy are - Councilman bodies Areas of lysed liver cells surrounded by collection of kupffer cells and inflammatory cells. Causes of Focal necrosis - Viral hepatitis, Bacterial infections, Toxic damage Zonal necrosis - The characteristic of zonal necrosis is that identical regions of liver lobules are involved. All liver lobules are involved. The necrosis is divided according to the zone involved (Note: In focal necrosis any area of lobule and some lobules are involved.) Types of zonal necrosis Centrizonal necrosis (centrilobular) ->> Necrosis in the cells surrounding central hepatic vein, seen in - i) Cardiac failure or shock iii) Chloroform toxicity ii) Carbon tetrachloride toxicity (CC14) iv) Viral hepatitis Peripheral zonal necrosis (periportal) - Necrosis is seen in areas around the portal tracts, Seen in i) Eclampsia ii) Phosphorus poisoning Midzonal necrosis - Rare, seen in yellow fever Also know - o Submassive necrosis - Occurrence of liver cell necrosis that is not limited by lobular boundaries i.e., the necrosis extends beyond lobular boundaries. o Massive liver necrosis - In this large areas of liver cell undergo necrosis. Only small areas are left intact, o Massive and submassive fiver necrosis are clinically manifested as. # Acute fiver failure of variable severity # Serum enzyme levels are very high