Pathology Misc. (R.B.C) 2f4645d8 Direct globulin test is positive in? A PNH B Sickle cell anemia C Thalassemia D Paroxysmal cold hemoglobinuria High-Yield Explanation Ans. (d) Paroxysmal cold hemoglobinuria(Ref: Robbins 9th/pg 642; 8th/pg 654)Direct globulin test is positive in Paroxysmal cold hemoglobinuria, as anti P antibody is formed.