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Pharmacology Miscellaneous (Pharmacology) 2f10d5fd

A 40 year old woman was on chemotherapy for 6 months for Ovarian carcinoma. Now she presented with a progressive bilateral Sensorineural hearing loss. The Drug responsible for this includes

A
Cisplatin
B
Doxorubicin
C
Cyclophosphamide
D
Paclitaxel
High-Yield Explanation
(A) Cisplatin# Platinum-containing chemotherapeutic agents, including cisplatin and carboplatin, are associated with cochleotoxicity characterized by high-frequency hearing loss and tinnitus.> Ototoxicity is less frequently seen with the related compound oxaliplatin.

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