Defect leading to thalassemia lies in –

Disorders off hemoglobin Disorders of hemoglobin may be of two types - 1)   Qualitative defect of hemoglobin (hemoglobinopathy) Hem oglobinopathies are disorders of hemoglobin, characterized by a defect that results in abnormal structure of one of the globin chain of hemoglobin. Examples are - Siclde cell anemia, HbC, HbE, HbD-Punjab, Hb O-Arab, Hb Lepore. 2)   Quantitative defect of hemoglobin These disorders are characterized by a defect that results in decreased rate of synthesis of one of the globin chain of hemoglobin. Example - Thalassemia