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Gynaecology & Obstetrics Choriocarcinoma 2f06f6de

Karyotype of Complete mole is?

A
46 XY
B
46 XX
C
69 XXX
D
69 XXX
High-Yield Explanation
ANSWER: (B) 46XXREF: Dutta 6th ed p. 201Repeat in December 2011See APPENDIX-63 for "COMPLETE AND PARTIAL HYDATIDIFORM MOLES" APPENDIX - 63Complete and Partial Hydatidiform Moles:FeaturePartial Hydatidiform MoleComplete Hydatidiform MoleKaryotype69XXY, Triploid, paternal and maternal origin46XX, Diploid, mostly paternal originImmunohistochemistryhCGWeakStrongPlacental alkaline phosphataseStrongWeakhPLvariableWeakPathology Fetus or amnion, fetal vessels Hydropic villiTrophoblastic proliferationPresentVariable, often focal FocalAbsentPronounced, generalizedVariable, often markedClinical Mole clinical diagnosisUterus large for datesMalignant sequelaeRareRare<5%Common30%-50%6%-36%

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