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Pathology General 2e71ccfe

Deficiency of GpIIb-IIIa results in which of the following condition?

A
Glanzmann thrombasthenia
B
Wiskot Aldrich syndrome
C
Bernard Soulier syndrome
D
None of the above
High-Yield Explanation
Platelet activation by ADP triggers a conformational change in the platelet GpIIb-IIIa receptors that induces binding to fibrinogen, a large protein that forms bridging interactions between platelets that promote platelet aggregation. Predictably, inherited deficiency of GpIIb-IIIa results in a bleeding disorder (Glanzmann thrombasthenia). Ref: Robbins 8th edition Chapter 4.

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