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Pediatrics General 2e5b6018

A 3–month old male child with normal genitalia presents to the emergency department with severe dehydration, hyperkalemia and hyponatremia. The measurement blood levels of which of the following will be helpful?

A
17–hydroxy progesterone
B
Renin
C
Cortisol
D
Aldosterone
High-Yield Explanation
This is a case of congenital adrenal hyperplasia due to deficiency of 21 - hydroxylase deficiency. Because of the enzyme block ,there is increased formation of 17- hydroxyprogesterone, which is then shunted into the production of testosterone. Levels of cortisol and aldosterone are reduced.

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