The vitamin K dependent protein C and S are characterised by their ability to inactivate factor:

Sequence of Events Involved in the Activation of Plasminogen During intravascular clotting, the endothelium of the blood vessel secretes a thrombin-binding protein, the thrombomodulin. It is secreted by the endothelium of all the blood vessels, except the minute vessels of brain. Thrombomodulin combines with thrombin and forms a thrombomodulin-thrombin complex. Thrombomodulin-thrombin  complex  activates protein C. Activated protein C inactivates factor V and VIII in the presence of a cofactor called protein S. Protein C also inactivates the t-PA inhibitor. Now, the t-PA becomes active. Activated t-PA and lysosomal enzymes activate plasminogen to form plasmin. Plasminogen is also activated by thrombin and u-PA.