Microbiology Virology 2e2a5531 Nef gene in HIV is for use- A Enhancing the expression of genes B Enhancing viral replication C Decreasing viral replication D Maturation High-Yield Explanation nef ( negative factor gene) down regulates viral replication. REF:ANANTHANARAYAN AND PANIKER'S TEXTBOOK OF MICROBIOLOGY 9TH EDITION PAGE NO-572