A fetus born to a mother with history of fever with rash in first trimester of pregnancy shows chorioretinitis, cerebral coical atrophy, cutaneous scarring and bone leg defects. Most probable cause is?
High-Yield Explanation
Maternal varicella during the first half of pregnancy may cause congenital malformations by transplacental infection called congenital varicella syndrome Eye defects: Microphthalmia, chorioretinitis, cataracts Neurological: microcephaly, cerebral coical atrophy, neurological dysfunction of bladder and bowel sphincters Cutaneous: scarring in dermatomal origin Bony defects: limb hypoplasia