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Pathology Hemoglobinopathies: Sickle cell anemia 2dab5235

Spherocytosis in peripheral blood smear is seen in which of the following?

A
Post-transfusion
B
Hereditary spherocytosis
C
Hemolytic disease of newborn
D
All of the above
High-Yield Explanation
Spherocytosis is seen in Hereditary spherocytosis Autoimmune hemolytic anemia Hemolytic disease of newborn Post-transfusion Heinz body hemolytic anemia (G6PD deficiency, etc.) Water-dilution hemolysis (IV water infusion or drowning (fresh water)) Fragmentation hemolysis (Burns, mechanical trauma) Spherocytes represent red cells, with the most decreased surface area:volume ratio seen in hereditary spherocytosis, immune hemolytic anemia, stored blood, Heinz body hemolytic anemia, and caused by cell fragmentation.

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