Lanatoprost used topically in glaucoma primarily acts by:

B i.e. Increased uveoscleral outflow Prostaglandin analogues (e.g. latanoprost Q, unprostone, bimatoprost, travoprost) lower intraocular pressure by stimulating a prostanoid receptor in ciliary muscle. This causes the release of matrix metalloproteinases and increase the uveoscleral outflow. Q Latanoprost lower IOP by 25-30% (equivalent to effect produced by timolol). Common side effects are conjunctival hyperaemia, superficial punctate keratopathy & pigmentation. Prostaglandin analogues and pilocarpineQ are contraindicated in inflammatory glaucoma (e.g. glaucoma with uveitis, hypeensive uveitis syndrome) Q. Prostaglandin analogues are 2nd drug of choice after )6 blocker in treatment of open angle glaucoma Q