Pharmacology General 2d44b51d

Which of the following metabolic abnormality is seen with long term use of spironolactone?

Metabolic acidosis

Metabolic alkalosis

Hyperkalemia

None of the above

High-Yield Explanation

By inhibiting H+ secretion in parallel with K+ secretion, the K+-sparing diuretics can cause acidosis similar to that seen with type IV renal tubular acidosis. Ref: Katzung, 11th edition, Chapter 15.

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Which of the following metabolic abnormality is seen with long term use of spironolactone?

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