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Which of the following statements is not true of local anesthetics?

A
The local anesthetic is required in the unionized form for penetrating the neuronal membrane
B
The local anesthetic approaches its receptor only from the intraneuronal face of the Na+ channel
C
The local anesthetic binds to its receptor mainly when the Na+ channel is in the resting state
D
The local anesthetic combines with its receptor in the ionized cationic form
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