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Unknown General 2cbf4798

Which is true hermaphroditism?

A
45 X0
B
45X0/46
C
46XX/46XY
D
47XY/47XX
High-Yield Explanation
Ref. The Short Textbook of Pediatrics. Pg 749   Hermaphroditism True’ hermaphroditism is a genetic condition in which affected individuals have both mature ovarian and testicular tissue. The entity is due to chromosomal and genetic cause . Both the testis and the ovarian tissue are present in an individual and in different combinations . Ovotestis on each side (commonest) Testis on one side ,ovary on other  . Testis or ovary on one side and ovotestis on the other . It is probable that fertilisation by a sperm carrying one X chromosome , which contains some male determinant material from Y gives rise to this condition . The common presentation is ambiguity of external genitalia . The internal structure depends on the degree of differentiation of associated gonad on that side . 75% develop gynecomastia and nearly 50% menstruate INVESTIGATIONS : Sex chromatin is usually positive Karyotype is usually 46 XX(70%) ,rest are 46 XY and rarely mosaic XX/XY Confirmation is done by gonadal biopsy

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