What is the mechanism of action of Fluconazole?

Ref. KDT. Page. 793 Fluconazole They inhibit the fungal cytochrome P450 enzyme ‘lanosterol 14-demethylase’ and thus impair ergosterol synthesis leading to a cascade of membrane abnormalities in the fungus. lower affinity for mammalian CYP450 enzymes and lesser propensity to inhibit mammalian sterol synthesis – causes less side effects It is a water-soluble triazole having a wider range of activity Indications include cryptococcal meningitis, systemic and mucosal candidiasis in both normal and immunocompromised patients, coccidioidal meningitis and histoplasmosis