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Pharmacology Autonomic nervous system 2c6fd3d2

True statements about neostigmine are

A
It is a quaternary ammonium compounds
B
It is metabolized by the liver
C
It can cross the blood brain barrier
D
Prominent effect on cardiac muscle
High-Yield Explanation
(Ref. KDT6/e p101-102; Lee 12/ep217) Neostigmine is a reversible cholinesterase inhibitor.It is a quaernary ammonium compound. (lipid insolube agent), so it does not cross blood-brain-barrie. It is paly hydrolyzed by serum cholinesterase and paly excreted unchanged by the kidneys. It possesses some agonistic action on NM receptors.

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