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Biochemistry General 2c43971d

Which of the following regarding sickle cell disease is false?

A
Single nucleotide change results in change of Glutamine to Valine
B
Sticky patch is generated as a result of replacement of a nonpolar residue with a polar residue
C
HbS provides resistance against malaria
D
Binding of deoxyHbA terminates fiber polymerization
High-Yield Explanation
In HbS, the nonpolar amino acid valine has replaced the polar surface residue Glu6 of the β subunit, generating a hydrophobic “sticky patch” on the surface of the β subunit of both oxyHbS and deoxyHbS. Ref: Harper’s illustrated biochemistry. 30th edition page no: 56
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