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Physiology Blood: Hemostasis and Blood Coagulation 2c2e9f9b

Ion which is needed for conversion of Prothrombin to thrombin is?

A
Sodium
B
Potassium
C
Magnesium
D
Calcium
High-Yield Explanation
ANSWER: (D) CalciumREF: Guyton's physiology 22nd edition page 459Conversion of Prothrombin to ThrombinFirst, prothrombin activator is formed as a result of rupture of a blood vessel or as a result of damage to special substances in the blood. Second, the Prothrombin activator, in the presence of sufficient amounts of ionic Ca++t causes conversion of Prothrombin to thrombin (Figure 36- 2). Third, the thrombin causes polymerization of fibrinogen molecules into fibrin fibers within another 10 to 15 seconds.

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