Full 2L QBank
Medicine All India exam 2be4e31f

Which channel is defective in "Malignant Hyperpyrexia"?

A
Sodium
B
Potassium
C
Calcium
D
Magnesium
High-Yield Explanation
Malignant hypehermia:Inheritance is autosomal dominanceThe defect is located on the long arm of chromosome 19 involving the Ryanodine receptor of the skeletal muscle sarcoplasmic reticulumThis is associated with L-type calcium channelsThere will be a rapid increase in intracellular calcium level in response to halothane and other inhalational anaesthetics or to succinylcholineFeatures are:Elevated temperature,increased muscle metabolism, muscle rigidity, rhabdomyolysis, acidosis and cardiovascular instability develop within minutesThis rare condition is often fatal (ref: Harrison's 17/e p118, 18/e p144)

Related Medicine MCQs

Practice 2,00,000+ NEET PG Questions Free

Timed mock tests, mistake queue analytics, audio lectures & zero attempt limits on i❤️Exams.

Start Free Mock Test Now