Physiology General 2bc9f73c The nerve impulse which leads to initiation of muscle contraction ? A Causes opening of the calcium channels which leads to increase in calcium ion concentration with use of sarcomere B Causes both the plasma membrane and the T tubules to undergo hyperpolarization C Inhibits Sodium entry in sarcomere D Is inhibited by binding of acetylcholine to receptors in the sarcoplasmic reticulum High-Yield Explanation No explanation provided.