A patient of cirrhosis with liver failure comes to you for stem cell transplantation your method will be?

Ans. (d) Transfer hepatic progenitor cells (HPCs) of same person for regeneration(Ref: Nature Cell Biology 17, 971 -983 (2015)Hepatocytes and cholangiocytes self-renew following liver injury. But after severe injury like cirrhosis and acute liver failure hepatocytes are increasingly senescent. In this case there are two options: first diseased-donor liver and living- donor transplantation, in which a just portion of a healthy donor's liver is used for transplantation or second hepatic progenitor cells (HPCs), which contribute significantly to restoration of liver parenchyma, regenerating hepatocytes and biliary epithelia, highlighting their in vivo lineage potency. The best option is D among the options.