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Pharmacology CHF, Angina Pectoris and Myocardial Infarction 2b7d5118

You decide not to prescribe sildenafil in a patient because the patient told you that he is taking an antianginal drug. Which of the following can it be?

A
Calcium channel blockers
B
b adrenergic blockers
C
Organic nitrates
D
Angiotensin conveing enzyme inhibitors
High-Yield Explanation
Nitrates act by increasing cGMP and sildenafil inhibits the breakdown of this compound (by inhibiting phosphodiesterase). Marked increase in cGMP levels may result in the profound hypotension and reflex tachycardia.

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