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Physiology Endocrinology 2b7c3285

Relaxation of skeletal muscle occurs by

A
Removal of Acetylcholine from synaptic cleft
B
Closure of nicotinic cholinergic receptor
C
Binding of calcium with troponin
D
Removal of sarcoplasmic calcium
High-Yield Explanation
Once the calcium ions have been released from the sarcoplasmic tubules and have diffused among the myofibrils, muscle contraction continues as long as the calcium ion concentration remains high. However, a continually active calcium pump located in the walls of the sarcoplasmic reticulum pumps calcium ions away from the myofibrils back into the sarcoplasmic tubules. This pump can concentrate the calcium ions about 10,000-fold inside the tubules. In addition, inside the reticulum is a protein called calsequestrin that can bind up to 40 times more calcium. Ref: Guyton 13th ed, p 94

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