What is the best antidepressant prescribed for a patient with hypotension and cardiac disease?

(D) Venlafaxine # VENLAFAXINE: A novel antidepressant referred to as serotonin and noradrenaline reuptake inhibitor (SNRI), because it inhibits uptake of both these amines but, in contrast to older TCAs, does not interact with cholinergic, adrenergic or histaminergic receptors or have sedative property.Trials have shown it to be as effective antidepressants as TCAs and may work in some resistant cases.> A faster onset of action has also been indicated.> Venlafaxine does not produce the usual side effects of TCAs; tends to raise rather than depress BP and is safer in overdose.> Side effects are nausea, sweating, anxiety, dizziness and impotence.