A 45 year old male known case of diabetes mellitus have HbA1c of 9.4 % after strict glycemic control. All of the following complications can be reversed except ?

The microvascular complications of both type 1 and type 2 DM result from chronic hyperglycemia. Whereas, evidence implicating a causative role for chronic hyperglycemia in the development of macrovascular complications is less conclusive. Improvement of glycemic control reduce nonproliferative and proliferative retinopathy, albuminuria , clinical nephropathy, and neuropathy .Maximum reduction occurs in neuropathy but we cannot cpmpletely reverse microvascular or microvascular complication of diabetes. good glycemic control will slow down or prevent the complication but cannot reverse the disease once it occured.