Medicine C.N.S 2a35f599 Shagreen patch is seen in- A Tuberous sclerosis B Neurofibromatosis C Sturge weber syndrome D Neurofibromatosis I High-Yield Explanation . *In tuberous sclerosis skin changes include ash leaf mailed,angiofibromas, adenoma sebaceum, shagreen patches often on lower back. Ref Harrison20th edition pg 2564