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Physiology Nervous System 29a5b07b

Which of the following is not permeable through the Blood Brain Barrier

A
Water
B
Lipophilic drugs
C
Gas
D
Proteins
High-Yield Explanation
Ans. (d) Proteins(Ref: Ganong, 25th ed/p. 607)Substances that crosses the Blood Brain Barrier easily are,#Water (using carrier protein Aquaporin -4)#Glucose (using glucose transporters GLUT 1 55K and GLUT 1 45K)#O2 #CO2 #Steroid hormonesSubstances that do not crosses the Blood Brain Barrier easily are,#Protein hormones#Dopamine#H+ ions#Bicarbonate ions

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