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Biochemistry General 291118de

Acetyl CoA carboxylase requires which vitamin for function:

A
Thiamin
B
Riboflavin
C
Biotin
D
Niacin
High-Yield Explanation
Bicarbonate as a source of CO2 is required in the initial reaction for the carboxylation of acetyl-CoA to malonyl-CoA in the presence of ATP and acetyl-CoA carboxylase. Acetyl-CoA carboxylase has a requirement for the B vitamin biotin. The enzyme is a multienzyme protein containing a variable number of identical subunits, each containing biotin, biotin carboxylase, biotin carboxyl carrier protein, and transcarboxylase, as well as a regulatory allosteric site. Ref: Harper 28th edition, chapter 23.

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