Best parameter for monitoring HIV disease progression is -

Ans. is 'c' i.e., Peripheral blood CD4 + Tcell counts with Plasma levels of HIV RNA Laboratory monitoring in HIV infection* The epidemic of HIV infection and AIDS has provided the clinician with new challenges for integrating clinical and laboratory data to effect optimal patient management.* The close relationship between clinical manifestations of HIV infection and CD4+ T cell count has made measurement of CD4+ T cell numbers a routine part of the evaluation of HIV-infected individuals.* The discovery of HIV as the cause of AIDS led to the development of sensitive tests that allow one to monitor the levels of HIV in the blood.* Determinations of peripheral blood CD4+ T cell counts and measurements of the plasma levels of HIV RNA plasma provide a powerful set of tools for determining prognosis and monitoring response to therapy.