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Pharmacology AIIMS 2019 28e47981

Which of the following is clinical use of tafenoquine?

A
Radical cure of Plasmodium vivax
B
Prophylaxis of malaria in pregnancy
C
Treatment of severe falciparum malaria
D
Treatment of endemic malaria in children < 2 years
High-Yield Explanation
Radical cure - About 8-30% P.v. cases relapse due to persistance of exoerythrocytic stage. Drugs which attack this stage (hypnozoites) given together with a clinical curative achieve total eradication of the parasite from the patient's body. Drug of choice for radical cure of vivax and ovale malaria is: * Primaquine 15 mg daily for 14 days * Tafenoquine is a new long-acting exoerythrocytic schizontocide, has been developed as a single dose anti-relapse drug for vivax malaria.

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