Which of the following drugs act by inhibiting DNA replication?

6 Mercaptopurineis purine antimetabolite therefore it preventsDNAreplication. Mitomycin C is an antitumor antibiotic that inhibits DNA synthesis by producing DNA cross-links which halt cell replication and eventually cause cell death. Actinomycin D acts by inhibiting DNA dependent RNA synthesis. Asparaginase is an enzyme that catalyzes the hydrolysis of l-asparagine to l-aspaic acid and ammonia. They inhibit protein synthesis in tumor cells by depriving them of the amino acid asparagine.