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Physiology General 288402eb

Action potential is initiated at the axon hillock/initial segment of neuron because:

A
Threshold for excitation is lowest
B
Neurotransmitter is released at this site
C
It is an unmyelinated segment
D
Has lowest concentration of voltage gated Na+ channel
High-Yield Explanation
Because the initial segment of the axon has the highest density of voltage­ sensitive Na+ channels and therefore the lowest threshold for generating an action potential.

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