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Biochemistry Molecular Genetics 28360d81

About peptidyl transferase true is:

A
Used in elongation and cause attachment of peptide chain to A-site of tRNA
B
Used in elongation and cause attachment peptide chain to P site
C
Used in initiation and cause 43S complex formation
D
Used in initiation and cause 48S complex formation
High-Yield Explanation
Ans. A. Used in elongation and cause attachment of peptide chain to A-site of tRNA(Ref: Harper 31/e page 403)The a amino group of the new aminoacyl-tRNA in the A site carries out a nucleophilic attack on the esterified carboxyl group of the peptidyl-tRNA occupying the P site (peptidyl or polypeptide site). At initiation, this site is occupied by the initiator met-tRNAi.This reaction is catalyzed by a peptidyl transferase, a component of the 28S RNA of the 60S ribosomal subunit.This is another example of ribozyme activity.

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