Anatomy Other topics and Adverse effects 275bc554

The mechanism of anti cancer action of fluoruracil is

Cross linking of double standard DNA and the resulting inhibition of DNA replication and transcription

Cytotoxicity resulting from metabolite that interferes with the production of dTMP

Irreversible inhibition of dihydrofolic acid reductase

Selective action of DNA polymerase

High-Yield Explanation

5-FU is an antimetabolite.it us a thymidine analogue and acts by conversion to 5'-dUMP .latter inhibits the formation of dTMP and result in Thymineless dealth of cells Ref-KDT 6/824

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The mechanism of anti cancer action of fluoruracil is

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