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Pharmacology General 26f7e15c

A three year old child is brought to the emergency department having just ingested a large overdose of an antihistaminic drug. This drug is a weak base capable of entering most tissues including the brain. On physical examination the heart rate is 100/ minute, blood pressure is 110/60 mm Hg and the respiratory rate is 20/ minute. In this case of poisoning:

A
Urinary excretion would be accelerated by administration of NH4Cl, an acidifying  agent
B
Urinary excretion would be accelerated by administration of NaHCO3, an  alkalinizing agent
C
More of the drug would be ionized at blood pH than at stomach pH
D
Absorption of the drug would be faster from the stomach than from the small intestine
High-Yield Explanation
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