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Pathology Breast 26d49d65

Which of the following is not true in relation to Osteosarcoma?

A
Paget's disease & prior irradiation are factors
B
Rb gene mutation is associated with hereditary variant
C
c-myc gene implicated in the genesis
D
Codman's triangle is the characteristic x-ray finding
High-Yield Explanation
c-myc gene implicated in the genesis is wrong. Osteosarcomas occur in all age groups, with a second peak occuring in elderly persons, usually in association with other conditions like pagets disease, etc. A triangular shadow on the x-ray film between coex and raised periosteum (codman triangle) is charecteristics of osteosarcomas. RB gene mutations account for 60%to70% cases of these tumors Robbins basic pathology 9th edition page no 776,777

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