Alternative parenteral drug for multi drug resistant malaria is

Multidrug-resistant P. falciparum malaria : Either aemether-lumefantrinec (1.5/9 mg/kg bid for 3 days with food) or Aesunatec (4 mg/kg qd for 3 days) plus Mefloquine (25 mg of base/kg--either 8 mg/kg qd for 3 days or 15 mg/kg on day 2 and then 10 mg/kg on day 3) Aemisinin and derivatives (aemether, aesunate) : Good oral absorption, slow and variable absorption of IM aemether; aesunate and aemether biotransformed to active metabolite dihydroaemisinin; all drugs eliminated very rapidly; t1/2: <1 h (Harrison's Principles of internal medicine, 20th edition, page 1699)