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Medicine Bleeding from the GUT and diseases of esophagus 2593506f

A 25 year old man has pigmented macules over the palms, soles and oral mucosa. He also has anemia and abdominal pain. Which one of the following is the most likely diagnosis?

A
Cushing's syndrome
B
Albright's syndrome
C
Peutz-Jegher's Syndrome
D
Incontinentia pigmenti
High-Yield Explanation
Cushing Syndrome Presents with lemon on sticks with hypeension and anemia Albright syndrome At least 2 / 3 features: 1. Polyostotic fibrous dysplasia 2. Cafe-au-lait skin pigmentation 3. Autonomous endocrine hyperfunction (eg, gonadotropin-independent) Peutz Jehgers syndrome Located primarily around the nose and mouth, on the hands and feet, and within the oral cavity. Associated with hamaomatous polyps. C/F -anemia, rectal bleeding, abdominal pain, obstruction, and/or intussusception Incontinentia pigmenti Major criteria (1) typical neonatal vasicular rash with eosinophilia (2) typical blaschkoid hyperpigmentation on the trunk fading in adolescence (3) linear, atrophic hairless lesions Minor criteria: (1) dental abnormalities (2) alopecia (3) wooly hair (4) abnormal nails

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