Medicine General 257c17b1

The pathogenesis of hypochromic anemia in lead poisoning is due to

Inhibition of enzymes involved in heme biosynthesis

Binding of lead to transferrin, inhibiting the transport of iron

Binding of lead to cell membrane of erythroid precursors

Binding of lead to ferritin inhibiting their breakdown into hemosiderin

High-Yield Explanation

Lead interferes with the synthesis of Heme. Deficiency of heme causes microcytic hypochromic anemia because heme is an integral part of hemoglobin and it is well known that hemoglobin deficiency causes microcytic hypochromic anaemia.

The pathogenesis of hypochromic anemia in lead poisoning is due to

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