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Pediatrics Miscellaneous 24e62322

A 3-year-old child has presented with abdominal lump and aniridia shown below. All genes are responsible for development of this condition except?

A
WT1
B
P53
C
Beta-catenin
D
K-ras
High-Yield Explanation
Ans. (d) K-ras gene.GeneWilms tumor characteristicFrequencyWT1Inselected-20%P-cateninUnselected-15% Tumors with WT1 mutations (-20% of total)-50%p53Anaplastic histology (-5% of total)-80% Image Source:

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