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Pharmacology Prostaglandins 241e8cb8

Aspirin is used for ischemic heart disease:

A
Inhibit TXA2 synthesis
B
Inhibit prostacyclin
C
Inhibit COX 2
D
Inhibit synthesis of endothelin
High-Yield Explanation
Ans. A. Inhibit TXA2 synthesisAspirin is irreversible COX inhibitor. At low dose 40-325mg they act as antiplatelet agent. They inhibit TXA2 synthesis which is platelet aggregator but also inhibit PGI2 which is platelet anti aggrator. But the net effect is TXA2 inhibition.

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