Less sedating antiemetic used in motion sickness and veigo

Meclizine and cyclizine are often used in preventing motion sickness and for sho-term treatment of veigo because they are less sedating than diphenhydramine and promethazine. Promethazine also causes antiemetic activity and is available as a suppository or for injection. Chlorpheniramine and brompheniramine, which are less sedating than diphenhydramine and promethazine, are often used alone or in combination with decongestants for allergies and colds. Cyproheptadine has antiserotonin activiry and may be useful in treating patients with carcinoid tUmor, where it blocks the effects of serotonin and histamine on smooth muscle. Aztemizole, loratadine, and terfenadine are nonsedating antihistamines that do not cross the blood-brain barrier. Ref: katzung 12th ed.