The renal biopsy of a 6–year–old boy with recurrent gross hematuria shows IgA nephropathy. The urinary protein excretion is 130 mg/day. Which of the following is the most appropriate next step in the management –
High-Yield Explanation
T/T of IgA nephropathy
There is no proven tit for IgA nephropathy.
The primary t/t is proper blood pressure control.
The drugs which have been proved useful are:-
i) Fish oil (It contains omega - 3 fatty acids).
It is an anti-inflammatory agent and it prevents the rate of renal progression.
ii) Immunosuppressive therapy -
It is done with corticosteroids with or without cytotoxic therapy.
iii) ACE inhibitors and Angiotensin II receptor antagonists -
Their role in reducing proteinuria and retarding the rate of renal progression is still to be determined.
iv) Prophylactic antibiotics and tonsillectomy -
It may reduce the frequency of gross hematuria but they have no effect on the progression of renal disease.