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Pediatrics General 23b52b4a

The renal biopsy of a 6–year–old boy with recurrent gross hematuria shows IgA nephropathy. The urinary protein excretion is 130 mg/day. Which of the following is the most appropriate next step in the management –

A
Administer corticosteroids
B
Give Azathiopiine
C
Start Cyclosporine
D
Urinary bag sample
High-Yield Explanation
T/T of IgA nephropathy There is no proven tit for IgA nephropathy. The primary t/t is proper blood pressure control. The drugs which have been proved useful are:- i)  Fish oil (It contains omega - 3 fatty acids). It is an anti-inflammatory agent and it prevents the rate of renal progression. ii)   Immunosuppressive therapy - It is done with corticosteroids with or without cytotoxic therapy. iii) ACE inhibitors and Angiotensin II receptor antagonists - Their role in reducing proteinuria and retarding the rate of renal progression is still to be determined. iv) Prophylactic antibiotics and tonsillectomy - It may reduce the frequency of gross hematuria but they have no effect on the progression of renal disease.

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