Viral enterotoxin is detected as a possible mechanism of pathogenesis in :

Mechanism of Rotavirus diarrhea : a. Rotavirus destroy mature enterocytes of proximal small intestine. Loss of absorptive villi and proliferation of secretory crypt cells – Secretory diarrhea Brush border enzymes are reduced so unmetabolized disaccharides accumulates resulting. – Osmotic diarrhea b. NSP4 = enterotoxin which alteres epithelial cell function and permeability causing secretory diarrhea. c. Virus evoke fluid secretion by the activation of enteric nervous system in intestinal wall.