Active moiety of CoA is

- Synthesis of coenzyme A from pantothenate occurs in a series of  reactions. Pantothenate is  first phosphorylated to  which  cysteine is  added. Decarboxylation, followed by addition of AMP moiety and a phosphate (each from ATP) results in  coenzyme A. -Coenzyme A serves as a carrier of activated acetyl or acyl groups (as thiol esters).