Otitis and osteomyelitis is seen in

The most serious complication of BCG vaccination is disseminated BCG infection.The most frequent disseminated infection is BCG osteomyelitis (0.01-43 cases per million doses of vaccine administered) which usually occurs 4 months to 2 years after vaccination.Fatal disseminated BCG infection has occurred at a rate of 0.06-1.56 cases per million doses; these deaths occurred primarily among immunocompromised persons.BCG otitis - A form of acute otitis media occasionally observed in infants after oral administration of BCG tuberculosis vaccine.In pus and granulation of the ear in a number of patients detected acid-bacteria vaccine strain BCG. Typically imperceptible onset at normal temperature, the growth of granulation tissue, for lingering, long-term, but beneficial.